Sponge lncrna
Web15 Mar 2016 · The determinants of sponge lncRNA efficacy. Although lnc-7 was predicted to share 22 miRNAs with PTEN, it had no regulatory effect on PTEN expression. We further investigated the mechanism, whereby lnc-7 was unable to serve as an effective miRNA sponge. The miRNA-induced repression occurs dominantly in the cytoplasm and is … WebIn recent years, breakthroughs in bioinformatics have been made with the discovery of many functionally significant non-coding RNAs (ncRNAs). The disc…
Sponge lncrna
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Web4 Sep 2024 · Background: Long non-coding RNAs (lncRNAs) can indirectly regulate mRNAs expression levels by sequestering microRNAs (miRNAs), and act as competing endogenous RNAs (ceRNAs) or as sponges. Previous studies identified lncRNA-mediated sponge interactions in various cancers including the breast cancer. Web10 Dec 2024 · Long noncoding RNAs (lncRNAs) belong to a group of abundant transcripts that are above 200 nucleotides in length and have no protein coding potential 1. LncRNAs …
WebLncRNA H19 participates as a sponge of miR-17, which targets STAT3 102 and miR-196b, a miRNA repressor of LIN28B whose reduced activity enhances tumor progression. 103 Importantly, upregulation of oncogenic lncRNAs that modify Wnt/β-catenin pathways is related to tumor growth in several cases, as occurs for SNHG1 104 and FOXD2-AS1. 105 … WebThis competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC …
Web2 Mar 2024 · LncRNAs are a class of non-coding RNAs that transcript longer than 200 nucleotides and have been implicated in regulating cancer cell proliferation, metastatic … WebFurther studies revealed that lncRNA TMPO-AS1 was largely located in the cytoplasm of HCC cell and sponge miR-320a, resulting in increasing the level of SERBP1 in HCC cell. ... Upregulation of lncRNA SNHG16 inhibits HCC cell proliferation and chemo-resistance via sponging miR-93. 8 LncRNA MIAT increases HCC cell proliferation and invasion by ...
WebAs previously mentioned, lncRNA Xist exerts its function in colorectal cancer cells’ development by serving as a miRNA sponge. Zhang et al. (2024e) reported that lncRNA …
Web13 Dec 2024 · The lncRNA-MD1 sponges miR-133 and miR-135 to protect the mRNA of the muscle-specific genes MAML1 and MEF2C [ 13 ], and lncRNA-RoR functions as a ceRNA and sequesters miR-145 to regulate the core transcription factors Oct4, Sox2, and Nanog in human ESCs [ 19 ]. colbe hotelWeb12 Aug 2007 · The stable miR-16 sponge–expressing cell line allowed threefold higher expression of a miR-16 target (relative to an untargeted control reporter) than the stable … col beighWeb23 Apr 2024 · Since the lncRNA related miRNA sponge interaction networks are created by simply putting together sponge lncRNA-mRNA pairs, when the expression levels of each sponge lncRNA-mRNA pair are highly correlated, the collective correlation between the set of sponge lncRNAs and the set of mRNAs in the same identified module is not necessarily … dr luther aiken sc southside pediatricscol behnWebMicroRNAs (miRNAs) are small regulatory RNAs that act in an entangled web of interactions with target mRNAs to shape the cellular protein landscape by post-transcriptional control of mRNA decay and translation. miRNAs are themselves subject to numerous regulatory mechanisms that adjust their prevale … dr lutch miltonWeb2 Feb 2024 · National Center for Biotechnology Information dr luthe bad bentheimWeb16 Mar 2024 · In other words, lncRNA acts as a miRNA “sponge” which prevents miRNA from binding to its targets. The expression of many lncRNAs strongly relates to their neighboring genes, which means they can function as cis-regulators. lncRNA transcription may influence adjacent genes in mostly positive or negative manners . dr luther alison