Mfsd2a inhibitor
Webb29 mars 2024 · MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment. Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis. Webb1 jan. 2013 · The Syncytin-2 receptor has been identified as MFSD2a [16], although no direct evidence for its role in trophoblast fusion had been presented. To investigate on its implication in trophoblast fusion, we used the BeWo cell …
Mfsd2a inhibitor
Did you know?
Webb1 feb. 2016 · Mfsd2a is the first inhibitor of the transcytosis and the first transporter for lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA) in BMECs. The crucial dual function of Mfsd2a puts forward two kinds of Mfsd2a-based strategies for carrying drugs from blood to the CNS. Webb通过伊文思蓝和白蛋白-Alexa594 的渗漏检测血脑屏障通透性。通过透射电子显微镜 (TEM) 检查 BBB 的超微结构。通过蛋白质印迹和免疫荧光染色定量Cav-1和Mfsd2a，通过蛋白质印迹定量AQP4、PDGFR-β、ZO-1和Occludin。 结果： Storax 0.1 g/kg 治疗对脑损伤没有 …
WebbWnt signaling directly controls the transcription of an endothelium-specific transcytosis inhibitor, major facilitator superfamily domain–containing protein 2a (MFSD2A), in a β-catenin–dependent manner. MFSD2A overexpression reverses Wnt deficiency–induced transcytosis in endothelial cells and in retinas. Webb16 juni 2024 · MFSD2A mediates uptake of the essential fatty acid DHA across the blood–brain barrier. ... Structural insights into the lysophospholipid brain uptake …
Webb23 okt. 2024 · To further dissect the mechanism of Mfsd2a inhibition, we cotransfected Mfsd2a along with individual ZIKV-encoded proteins into human embryonic kidney (HEK) 293T cells. ZIKV E protein, but not other viral proteins, disrupted Mfsd2a expression ( Fig. 2A ), which is in line with immunofluorescence results indicating the loss of stable … WebbThe expression of Mfsd2a, the LPC-DHA transporter, was reduced in the oxygen-induced retinopathy (OIR) model and streptozotocin (STZ) model. In vitro, Mfsd2a …
WebbMfsd2a is specifically expressed on the cell membrane of brain-microvascular endothelial cell (BMEC) and is implicated in the delivery of some substances across the BBB. Mfsd2a is the first inhibitor of the transcytosis and the first transporter for lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA) in BMECs.
Webb19 sep. 2024 · This first strategy of MFSD2a inhibition was recently realized by Ju where tunicamycin conjugated nanoparticles inhibited MFSD2a activity for the transport of chemotherapy into a murine brain . While this approach was used to treat breast metastases in the brain, a similar approach could be used as a delivery strategy for … intertech contractsWebb包含至少一个检索词. 不包含检索词. 出现检索词的位置 intertech contracts ltdWebb14 apr. 2024 · Potential substrates for MMP9-mediated degradation include endothelial cell tight junction proteins, components of the glycocalyx, as well as the transporter Mfsd2a. B, Once tumor cells transverse the BBB and endothelial basement membrane, MMP9 expression promotes capillary remodeling, including the formation of intralumenal … new garden road greensboro north carolinaWebb19 aug. 2024 · MFSD2A is a sodium-dependent lysophosphatidylcholine symporter that is responsible for the uptake of docosahexaenoic acid into the brain1,2, which is crucial for the development and performance... intertech contracts ukWebb21 mars 2024 · The MFSD2B homologue, MFSD2A, has been identified as a lysophosphatidylcholine transporter in endothelial cells of the blood-brain barrier 16. The protein sequence for mouse MFSD2A showed... new garden road restaurantsWebb4 aug. 2024 · 据悉，MFSD2A 是一种钠依赖性溶血磷脂酰胆碱同向转运蛋白，负责将二十二碳六烯酸摄取到大脑，这对大脑的发育和性能至关重要。. 影响 MFSD2A 的 ... new garden rowland heightsWebb16 juni 2024 · SYNC2 establishes an extensive binding interface with MFSD2A, and a SYNC2-soluble fragment acts as a long-sought-after inhibitor of MFSD2A transport. new garden pullman wa