Josephin family protein

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August undefined, 2024

NettetHi All, I'm currently recruiting for this position. Please click on the job title below to view the Job Description and apply to it! NettetThe Josephin domain is an eukaryotic protein module of about 180 residues, which occurs in stand-alone form in Josephin-like proteins, and as an amino- terminal …

Structural insights into the activity and regulation of human Josephin ...

NettetThis gene codes for a deubiquitinating enzyme (DUB) that belongs to a gene family, that in humans is composed by three more genes (ATXN3L, JOSD1, and JOSD2), that … Nettet23. aug. 2005 · A recent classification defined the ataxin-3/Josephin family as one of five distinct families of deubiquitinating enzymes ( 11 ). The UIM is a conserved 15-aa motif first discovered as a polyubiquitin binding domain in the S5a proteasome subunit ( 12 ). the george hotel stamford lincolnshire

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Deubiquitinating enzyme Josephin-2 stabilizes PHGDH to

Crystal Structure of a Josephin-Ubiquitin Complex

Nettet21. jan. 2024 · All MJD proteins share a common globular catalytic cysteine protease domain of ∼180 amino acids, known as the Josephin domain. ATXN3 and ATXN3L sequences consist of the Josephin domain and a disordered C-terminal tail where the polyQ tract and two or three ubiquitin-interacting motifs (UIMs) are located. Nettet26. sep. 2011 · Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at least 98 DUBs ... the george hotel stamford restaurantNettetTTHERM_00661710 josephin family protein [] Gene ID: 7835909, updated on 10-Sep-2016. Summary. Gene provides a unified query environment for genes defined by … the app bouncy balls

"Nettet28. feb. 2005 · The Josephin domain plays an important role in the cellular functions of ataxin-3, the protein responsible for the neurodegenerative Machado-Joseph disease. … " - Josephin family protein

Josephin family protein

Nettet28. feb. 2005 · We have determined the solution structure of Josephin and shown that it belongs to the family of papain-like cysteine proteases, sharing the highest degree of structural similarity with bacterial staphopain ... Macromolecules Find similar proteins by: (by identity cutoff) 3D Structure Experimental Data & Validation Experimental Data http://iuucd.biocuckoo.org/BrowseGeneral.php?enzyme=DUB&fam=DUB/Josephin&spe=Homo_sapiens#:~:text=Josephin%20family%20represents%20DUBs%20with%20a%20papain-like%20cysteine,which%20resembles%20that%20of%20UCH%20domain%20deubiquitinating%20enzymes.

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Nettet21. aug. 2024 · The MJD family of human deubiquitinating enzymes contains four members: Ataxin-3, the ataxin-3-like protein (AT3L), Josephin-1, and Josephin-2. All share a conserved catalytic unit known as the Josephin domain. Ataxin-3 and AT3L also contain extensive regulatory regions that modulate their functions … Nettet2. des. 2013 · We found that PTEN expression was induced by depleting any of three members of the Josephin family DUBs: ataxin 3 (ATXN3), ataxin 3-like (ATXN3L) and Josephin domain containing 1 (JOSD1). However ...

Nettet21. feb. 2024 · This gene codes for a deubiquitinating enzyme (DUB) that belongs to a gene family, that in humans is composed by three more genes (ATXN3L, JOSD1, and … NettetJosephin family protein. Gene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. Bma-atx-3 Josephin family protein [] Gene ID: 6098503, updated on 4-Nov-2024. Summary. Other …

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NettetGene ID: 5477148, updated on 14-Nov-2024. Summary Other designations. Josephin (Ataxin-3) family protein the george hotel swaffham menuNettet30. des. 2024 · Josephin proteins are widely distributed and highly conserved in all eukaryotes, which implies the important roles of the proteins in these family. … the george hotel south melbourne menuNettetJosephin domain-containing protein 1 Gene names Name JOSD1 Synonyms JSPH1, KIAA0063 Organism names Organism Homo sapiens (Human) Taxonomic identifier … the george hotel swazilandNettet1. sep. 2007 · The neurodegenerative disease spinocerebellar ataxia type 3 (SCA3) is caused by the presence of an extended polyglutamine stretch (polyQ) in the unstructured C-terminus of the human ataxin-3 (AT3) protein. The structured N-terminal Josephin domain (JD) of AT3 is conserved within a novel family of potential ubiquitin proteases, … the george hotel stamford ukNettetJosephin family represents DUBs with a papain-like cysteine protease catalytic domain. As a well studied Josephin family protein of Ataxin-3, the structure of the Josephin domain was solved by NMR which resembles that of … the george hotel stoke on trentNettetTTHERM_00661710 josephin family protein [] Gene ID: 7835909, updated on 10-Sep-2016. Summary. Gene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer. TTHERM_00661710 josephin family protein [] Gene ID: 7835909, updated on ... the george hotel stamford lunch menuNettet10. apr. 2024 · In the Nature Cancer study, researchers led by Dana-Farber found that some tumors that test negative for the AR do express PSMA and that some AR-positive tumors don't – which led them to look for a control mechanism that doesn't involve the AR. Their search revealed that the HOXB13 protein as a key regulator of PSMA. theappbuilder.com