WebFeb 3, 2024 · Hyperammonemia is a severe pathological condition characterized by an increase in the concentration of ammonia (NH3) in the blood serum of more than 60 mmol/l. The causes may be genetically determined defects of ornithine cycle enzymes in the liver or severe liver diseases (hepatitis, cirrhosis). The main clinical symptoms include repeated ... WebMar 1, 2024 · This side effect can lead to VPA-induced hyperammonemic encephalopathy, which causes neurological slowing and electroencephalography changes; these changes can be reversible, but if untreated, may ultimately induce life-threatening coma. 2 Risk factors for VPA-induced hyperammonemia include concurrent topiramate use, urea cycle …
Valproic acid-induced hyperammonemia: Incidence, clinical significance ...
WebSep 1, 2011 · The encephalopathy observed in this case was a consequence of hyperammonemia caused by reduced cellular glutamate uptake and activation of N -methyl-d-aspartate receptors ( 1 ). The VPA metabolite 2-propyl-2-pentenoic acid, a known neurotoxin, may also have contributed to the encephalopathy. bing lee logitech headset
Cause for Confusion: Noncirrhotic Hyperammonemic …
WebSep 1, 2007 · The use of valproic acid (VPA) (also known as Depakote, Depakene, and others) frequently results in elevated plasma ammonia. In some people, … WebMar 1, 2024 · Valproic acid-induced hyperammonemic encephalopathy may occur in people with normal liver function, despite normal doses and serum levels of valproic acid (VPA). ... ... Treatment with Lcarnitine... WebSep 11, 2015 · In the absence of hepatic dysfunction, VPA can cause a decrease in the hepatic urea synthesis. VPA causes an increase in ammonia production in the kidneys by its effects on decreasing the synthesis of glutamine, inhibition of carbymol phosphate synthase, and by reduction of hepatic ammonia metabolism by decrement of carnitine … d1 college women\\u0027s soccer rankings 2021