WebJul 4, 2024 · Highly active antiretroviral therapy (HAART) is a treatment regimen typically comprised of a combination of three or more antiretroviral drugs. HAART may also be … WebMar 3, 2024 · The elevated levels of neurofilaments in serum (sNfL) have been associated with the disease activity, including the number of relapses, Gd-enhancing lesions, and paramagnetic rim MRI lesions. Therefore, sNfL levels could represent a potential biomarker in predicting MS disease activity and progression ( 32 ).
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WebJun 3, 2024 · 81. Ziemssen T, Bass AD, Berkovich R, Comi G, Eichau S, Hobart J, et al. Efficacy and safety of alemtuzumab through 9 years of follow-up in patients with highly active disease: post hoc analysis of CARE-MS I and II patients in the TOPAZ extension study. CNS Drugs. (2024) 34:973–88. doi: 10.1007/s40263-020-00749-x WebBackground We aimed to determine the proportion of highly active multiple sclerosis patients under high-efficacy therapies (HETs) achieve no evidence of disease activity-3 (NEDA-3) at 1 and 2 ... diary of knitting sititches
Defining highly active disease. Download Scientific Diagram
WebAlemtuzumab is included as a recommended treatment for patients with highly active disease (HAD) by the American Academy of Neurology Practice Guidelines, and the label indication in Europe was recently restricted to the treatment of HAD patients. WebMay 1, 2024 · Referred to as having ‘highly active’ MS (HAMS), these patients are at increased risk of poor prognosis. This definition encompasses the failure of conventional … WebSep 18, 2015 · Therefore, among patients who meet criteria for active disease, consideration of initiation of alemtuzumab is warranted. Additionally, the efficacy of alemtuzumab in challenging cases with HARRMS points toward its potential role in patients requiring early and aggressive immunomodulation to prevent severe disability accumulation. diary of lies